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- Three distinct pharmacological actions have been implicated in the antimigraine effect of the triptans
- Stimulation of presynaptic 5-HT1D receptors, which serves to inhibit both dural vasodilation and inflammation
- Direct inhibition of trigeminal nuclei cell excitability via 5-HT1B/1D receptor agonism in the brainstem and
- Vasoconstriction of meningeal, dural, cerebral or pial vessels as a result of vascular 5-HT1B receptor agonism.